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KMID : 0363319760010010025
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Journal of Korean Oriental Internal Medicine
1976 Volume.1 No. 1 p.25 ~ p.34
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THE STUDY ON THE ACTIVITIES OF COMMERCIAL MISTLETOE IN NORMAL ADULT RABBITS & MOUSE
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Abstract
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The extract of commercial mistletoe caused transient contraction of mouse ileum in vitro at the level of 7x 10-4g/ml and augmented significantly its peristalsis. When the ileum was pre-treated. With 10-sglmll of adrenaline the administration of the extract at a level of 10-4g/ml blocked the contraction. The increase inperistalsis and intention was. also observed in rabbit ileum in vitro with the administration of the extract at a level- of 10-Ig/ml but these phenomenon were inhibited by the adrenaline treatment at a level of 10-1,g/ml.
When the extract was applied to spirally cut strips of thoracic aorta at the level of 10-3 g/ml the contractile action of adrenaline was significantly inhibited.
When the extract was infused to auricular blood vessel of rabbit at the rate of 10-4g/ml, l0-3g/ml, 10-2g/ml and 10`1g/ml increases in number of drops by 70%, 77%, 93 yo and 100% were observed if the maximum number of drops caused by 10-´g/ml is considered to be 100%. The duration of prolongation was proportionate to the increase in concentration of the extract.
Hypotensive action of the extract and its duration were proportionately incre-ased as the quantity of the extract increased. The increase in number and depth of respiration observed during the hypotensive status was brought to the normal when the tension became normal.
In view of these observations it is concluded that the extract of commercial mistletoe has a contractile action of acetylcholine effect in the ileum of mouse and rabbit, loosens both aorta and smooth muscle and promotes peripheral circu-lation. As for the hypotensive action it is concluded that the action is brought about by the decrease in peripheral circulatory resistance due to the antagonism between acetylcholine and adrenaline.
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